Skip to main content

Applications for Natural Products

IMSERC has a large pool of modern instrumentation for synthetic chemists. Our center is integrated with the Chemistry Department at Northwestern University where scientists run their experiments on a 24/7 basis. From monitoring reactions to full structure elucidation, researchers and students have access to a variety of techniques that can be used for:

Crystallographic atomic structure determination, identification, and refinement of organic and inorganic compounds for extraction of structural information such as:

Determination of unit cell and bonding environment (bond-lengths, bond-angles, cation-anion coordination, site-ordering, etc.)

Determination of packing of molecules and co-crystals

Determination of Hydrogen bonding

Determination of enantiomers

Refinement of modulated and twinned structures (incommensurate, commensurate, composite superstructures)

High resolution data for charge density measurement and precise assignment of atoms with similar chemical environment

Powder evaluation of sample purity (sensitivity of ~2% by weight)

Quantitative determination of individual crystalline phases and impurities in mixtures of powder

Monitor reactions in real time as a function of time, temperature, pressure, and gas flow/pressure

Probe catalytic changes to substrates

Investigate decomposition mechanism

In-situ monitoring of crystallization processes with increasing temperature

Mass Spectrometry

Nuclear Magnetic Resonance

NMR structure elucidation of natural products and unexpected reaction products

Structure elucidation and verification

Quantitative NMR and Purity determination

Determination of the stereochemistry: cis and trans isomerism, optical purity

Thermal analysis which can be coupled with GC-MS for the determination of:

Melting point using either Differential Thermal Analysis or Differential Scanning Calorimetry

Crystallization transition using either Differential Thermal Analysis or Differential Scanning Calorimetry

Glass transition using Differential Scanning Calorimetry

Decomposition temperature using ThermoGravimetric analysis which can be coupled with GC-MS for the identification of the decomposition products

Temperature of combustion with ThermoGravimetric analysis and identification of combustion volatiles using GC-MS

Qualitative and Quantitative elemental analyses

Halide determination (Chlorine, Bromine, Iodine) in solids or liquids using X-ray Fluorescence Spectroscopy

Survey of impurities and elements heavier than Sodium with X-ray Fluorescence Spectroscopy

Optical spectroscopy

Determination of functional groups and likely solvent molecules using Infrared (IR) spectroscopy

Vibrational stretches using Raman and IR Spesctroscopy

Color, band gap, and absorption measurements using Ultra-violet (UV), visible (Vis), and IR spectroscopies

Photoluminescence, lifetime phosphorescence, and emission measurements using spectrofluorimeter

Optical rotations and quantification of enantiomers using polarimetry