Any multidimensional NMR experiments to obtain NOE data in large uniformly labeled biomolecules are based on the conventional NOESY pulse scheme in which heteronuclear filters are incorporated to select or to filter the desired isotope nuclei.

2D Experiment	3D Experiment	4D Experiment
2D NOESY	-	-
2D w2-edited NOESY	3D NOESY-HMQC	-
2D w1-edited NOESY 2D HMQC-NOESY	3D HMQC-NOESY	-
2D w1,w2-edited NOESY	3D HMQC-NOESY-HMQC	4D HMQC-NOESY-HMQC

Such experiments can be designed with diferent options:

By replacing the HMQC pulse train by the HSQ or a TROSY pulse train in the conventional X half-filter. Thus, for instance , the 2D HMQC-NOESY experiment gives the same type of spectra as the 2D HSQC-NOESY or the 2D TROSY-NOESY experiments.

By using any combination between ¹³C and ¹⁵N isotope labeling. Thus, we can use the 3D NOESY-¹H-¹³C-HMQC experiment to obtain ¹H to ¹H{¹³C} NOE in D₂O samples whereas the 3D NOESY-¹H-¹⁵N-HMQC experiment is used to extract ¹H to ¹H{¹⁵N} NOE in H₂O samples.

By combining editing and filtering purposes. Thus, we can use a 3D ¹H-¹⁵N-edited-HMQC-NOESY-¹H-¹⁵N-edited-HMQC for studying intramolecular protein NOE contacts in protein-ligand complexes dissolved in H₂O whereas the 3D ¹H-¹⁵N-edited-HMQC-NOESY-¹H-¹⁵N-filtered-HMQC experiment can be used for studying the corresponding intermolecular protein-ligand NOE contacts.

Use of 2D, 3D or 4D versions as a function of the required information. Thus, in a 2D w₂-¹³C-edited NOESY experiment we obtain a 2D ¹H-¹H map with ¹H-¹H{¹³C} NOE whereas the the 3D NOESY-¹H-¹³C-HMQC experiment we also obtain ¹³C chemical shift information and better resolution from the third dimension.