The DQ/ZQ method which allows the measurement and the sign determination of coupling constants in large biomolecules amd greatly reduces the effects of differential relaxation.Examples:
- 3D DQ/ZQ+SQ-HNCA experiment
- 97JMR503-124
- 97JACS5425
- 98JMR216-135
99JACS6275 - 99JMR273-139