The selective 1D HMQC experiment is the selective version of the HMQC experiment. It allows to obtain the ¹H satellites resonances of a selected ¹³C nucleus. This experiment is also known as SELINCOR (SELective INverse detection of C,H CORrelation).

Easy implementation on AVANCE spectrometers equipped with an inverse probehead and selective excitation using shaped pulses.

The selective 1D HMQC pulse sequence is easily derived from the conventional four-pulse 1D HMQC experiment in which one of the two 90º ¹³C pulses is made selective for a given ¹³C resonance ( 89JMR561-81 and 90MRC696 ). A BIRD-recovery delay cluster is incorporated as a preparation period to suppress the large and undesired ¹H-¹²C magnetization.

Related modified sequences have been proposed:

• Analog selective 1D reverse-INEPT ( 87MRC297 , 94JMRA94-107 , 94JMRA95-110 , and 94JMRA90-110 ) experiment has been proposed for the same purpose.
• Selective 1D inverse experiment using chemical shift-selective filters ( 93JMRA98-101 and 93JMRB1-101 ) as a selective ¹³C excitation scheme.
• Better results are obtained from the gradient-enhanced version (see selective ge-1D HMQC, selective ge-1D HSQC and selective ge-1D reverse INEPT experiments).
• The same idea to replace a hard ¹³C pulse by a selective ¹³C pulse can be used to design semi-selective 2D experiments from the conventional 2D pulse sequences.
• The same experiment can be optimized to long-range heteronuclear coupling in order to measure ⁿJ(CH) values (see selective 1D HMBC experiment).

The selective 1D HMQC  experiment can be recorded in a fully automated way. Minor changes from a predefined parameter set are required. The most important parameter to define is the selective ¹³C pulse: the offset, the shape, the duration and the power level needed for a specific excitation profile.

For further details on practical implementation of the selective 1D HMQC  experiment on AVANCE spectrometers see Tutorial: selective 1D HMQC experiment

The selective 1D HMQC  experiment only displays the ¹H satellites resonances of a selected ¹³C nucleus. If ¹³C decoupling is applied during ¹H acquisition, the doublet due to ¹J(CH) is collapsed to a singlet.