Implementation on AVANCE spectrometers equipped with a triple-resonance probehead is feasible. Improved versions using pulsed field gradients (PFGs) are also available and, therefore, in such cases gradient technology is required. The experiment is recorded on a ¹³C,¹⁵N-labeled protein in H₂O.

The 4D HN(COCA)NH sequence was described in 93JACS4369 and it is a higher-dimension version of the 3D (H)N(COCA)NH experiment. A new version using heteronuclear cross-polarization were presented at 95JB323-89 .

The 4D HN(COCA)NH experiment can be recorded in automation mode.