Nucleic acids are polymers, the monomeric unit being a nucleotide that consists of three basic elements:
  • A pyrimidine or purine base. There are typically only four different bases in either DNA or RNA. In addition to the contents of Cytosine (C), Guanine (G) and Adenine (A), the only difference between DNA and RNA is that DNA contains thymine (T) and RNA uracil (U).
  • A sugar residue: beta-D-Ribose in RNA compounds and 2"-Deoxy-beta-D-Ribose in DNA compounds
  • Phosphodiester linkages between 3' and 5' positions of sugar moieties.
Important aspects to consider: General Reading:
  • DNA triplexes, Quadruplexes, and Aptamers ( 96ENC1726 )
  • RNA structure and function: Modified Nucleosides ( 96ENC4151 )