Saccharide NMR

  • 1H-1H coupling constants play an important role to determine ring conformation. However, strong coupling effects and overlapping can difficult the analysis. The measurement is performed in the usual way. Specific experiments:
  • cosine-modulated 2D HSQC ( 02JACS7235 )
  • One-bond ( 95JACS8645 ) and long-range proton-carbon coupling constants ( 95ACC15 , 95JACS8635 , 97JACS1737 , 97JACS8946 , 99JACS9843 , 99JPCA3783-103 , 00JOC4153 , and 00JPCA9443 ) have been also used in conformational studies
  • Carbon-carbon coupling constants in 13C-labeled compounds. ( 92JACS3499 , 93JACS10863 , 96JMRB69-112 , 97JACS1737 , 97JACS8946 , 98CRS335 , 99JACS9843 , 99JPCA3783-103 , 00JACS396 , 00JOC4153 ).
  • Two-bond carbon-carbon coupling constants ( 96CRS177 )
  • Three-bond COCC coupling constants ( 98JACS11158 )

  • Also see Conformational studies using dipolar couplings
  • J couplings through hydrogen bonds involving OH ( 02OL1831 )