Protein-Protein Complexes  

General reading: 01METH238-339, 01METH377-339 and 02BIO1

Some examples:

  • Also see protein-peptide complexes and oligomeric proteins
  • Probably, a reduced number of residues are responsible for most interaction energy in protein-protein interactions. Trp, Tyr and Arg seem to be the most frequent residues in protein's hot spots and therefore, techniques for selective isotope labeling for these reseidues are appealing. Mapping based on chemical shit changes using selective labeling in 1H/13C and 1H/15N spectra of complexes have appeared (( 00JACS7898, 03JACS2892 and 03JACS14250)
  • The solution structure of a protein-protein complex has been described in 99NAT166.
  • Chemical shit changes in ubiquitine and the conjugation enzyme UBC1 complex ( 00JB319-18)
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