Intermolecular NOEs are the key source for distance restraints in biomolecular complexes
  • Inter-ligand NOE (ILOE) in ternary complexes involving two or more ligands binding to a macromolecular receptor ( 99JB71-15 and 99JMR301-141).
  • Transferred NOE experiments in weakly-binding ligands
  • Isotope-edited NOE experiments in tightly bound ligands ( 96JB48)
  • Simultaneous measurement of intra- and intermolecular NOEs in protein ligand complexes using a semi-constant J-resolved 4D experiment ( 00JACS9735) and a simultaneous NOESY-13C/15N-HSQC pulse scheme ( 01JB107-21)