Drug-Protein Complexes   

Excellent review in ( 98PROG109).

Some examples:

  • Cyclophylin / cyclosporin complex ( 93NAT88, 94JB463)
  • FK506 binding protein / ascomycin complex ( 93BIO754, 00JACS1241)
  • Lactobacillus casei dihydrofolate reductase / methotrexate complex ( 98JMB119-277)
  • HIV-1 protease / DMP323 complex ( 96PRO495-5)
  • MDM2 and a small molecule inhibitor ( 04JB163-30)

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