Chemical-Shift can be encoded in a multi-dimensional NMR experiment into the line-shape of the corresponsing cross-peak through an apparent scalar coupling constant. Examples: 3D HNCAcodedHA experiment ( 03JB281-25 ). A typical 3D HNCA map is obtained but in the CA dimension an apparent doublet is obtained displaying the HA chemical shift. 3D TROSY-HNCAcodedCB and 3D TROSY-HNCAcodedCO experiments ( 04JB289-28 )
