Band-Selective Decoupling
Homonuclear decoupling has been used to simplify the spectrum and to enhance the corresponding signal-to-noise ratio. However, low-power broadband decoupling sequences generate large far-from-resonance frequency modulation which preclude selectivity. Selective band-decoupling can be achieved by using shaped inversion pulses combined in the same way as MLEV or WALTZ schemes ( 91JMR653-93 , 92JMR426-97 , 92JMR604-100 ). For instance, several approaches have been proposed:

Homonuclear decoupling ( B99KRI149) has been used intensively in double- and triple-resonance multidimensional experiments:

  • Homonuclear adiabatic decoupling during proton acquisition in 2D 1H-15N HSQC experiment ( 99JB335 )
  • Decoupling CO and/or CB spins from CA spins. Some examples are: 2D HSQC ( 96JMRB309-110 ), 3D HCCH-TOCSY ( 96JMRB190-113 ), 3D HNCA ( 96JMRB91-113 ), 3D HN(CO)CA ( 96JMRB91-113 ) experiments.
  • More about selective adiabatic inversion pulses : 97JMR221-126 and 97JMR115-129 .

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