Implementation on AVANCE spectrometers equipped with a triple-resonance probehead is feasible. Improved versions using pulsed field gradients (PFGs) are also available and, therefore, in such cases gradient technology is required. The experiment is recorded on a ¹³C,¹⁵N-labeled protein in D₂O.

The 4D HCACON sequence was described in 91JMR422

The 4D HCACON experiment can be recorded in automation mode.