Implementation on AVANCE spectrometers equipped with a triple-resonance probehead is feasible. Improved versions using pulsed field gradients (PFGs) are also available and, therefore, in such cases gradient technology is required. The experiment is recorded on a ¹³C,¹⁵N-labeled protein in H₂O.

The 4D (H)CACOCANH sequence was described in 95JB189

The 4D (H)CACOCANH experiment can be recorded in automation mode.