Implementation on AVANCE spectrometers equipped with a third channel. Improved versions using pulsed field gradients (PFGs) are also available and, therefore, in such cases gradient technology is required.

The 3D (H)NNH-TOCSY experiment is applied on ¹³C,¹⁵N-labeled proteins in H₂O.

The 3D (H)NNH-TOCSY experiment has been described in 97JB403-10 .

See list of 3D triple-resonance NMR experiments for doubly-labeled proteins.