.

Implementation on AVANCE spectrometers equipped with a third channel. Improved versions using pulsed field gradients (PFGs) are also available and, therefore, in such cases gradient technology is required.

The 3D H(N)COCA experiment is applied on ¹³C,¹⁵N-labeled proteins in H₂O.

The original H(N)COCA experiment was proposed in 99PROG93 ).

Related Experiments:

3D HN(CO)CA experiment

2D HN(CO)(CA) ( 91JMR413-94 )

3D HN[COCA] ( 95JB202 and 95JMRB197-108 )

See list of 3D triple-resonance NMR experiments for doubly-labeled proteins.