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Fluorine NMR

PHYSICAL PROPERTIES
 

Isotope
Natural 
Abundance
(%)
Nuclear
Spin
(I)
Magnetogyric
ratio
(107*rad/T*s)
Quadruple 
moment
(1028*Q/m2)
Resonance
frequency
(MHz)
at 11.744T
(500 MHz for 1H)
Relative 
sensitivity
(1H=1.00)
Absolute 
sensitivity
(1H=1.00)
19F
100
1/2
25.18148
0
470.385
0.83
0.83
 

APPLICATION FIELDS

 19F NMR spectroscopy offers an excellent sensitivity and for this reason is successfully applied on fluorine-containing compounds (pharmaceuticals compounds, mixtures of element-halides or anionic compounds ...). Solid-state NMR applications has also been reported.
NMR REFERENCES
CCl3F is used as a standard reference sample. Its absolute frequency is 94.094011 MHz with respect to 100.00 MHz of TMS. Also see IUPAC recommendations for reporting the NMR chemical shits of all nuclei relative to the 1H resonance of TMS (02JMR323-156).
NMR PARAMETERS
19F chemical shifts cover a range of 1300 ppm.
 A great number of coupling constants values for any 19F-X spin sytem are available. The most reported has been the 1H-19F ( 01JMR179-152 ) and 19F-19F coupling constants measurements.
NMR EXPERIMENTS
1D 1H-decoupled vs 1H-coupled 19F experiments. Alternatively, selective 1H decoupling can be also used.
1D 19F-decoupled vs 19F-coupled 1H experiments. Alternatively, selective 19F decoupling can be also used.
2D 19F-19F COSY experiment.
2D 1H-19F HETCOR experiment ( 91MRC387 ).
2D 13C-19F HETCOR experiment ( 94JMRA158-107 , 92JORG57 ).
1D 1H{19F} difference NOE experiments ( 97JFC47 )
2D19F-1H HOESY experiment ( 99ORG4367 , 02JACS4570 ).
1D & 2D 1H-19F HOESY experiment using gradients ( 99MRC647 )
2D 1H-19F HMBC experiment
2D 15N-19F IMPEACH-MBC experiment ( 02MRC207 )
BIBLIOGRAPHY
 Interesting review in: B97BER398, 00ENC489
High-resolution Solid State NMR ( 00ENC813 )
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