Labeling Strategies

  • Site-specific 100% isotope labeling is straightforward but costly alternative ( 97JB55 ).
  • Site-specific low-enrichment 15N,13C ( 02JACS1160 and 02JB257 ).
  • Solid-phase synthesis of selectively labeled DNA. Application to NMR ( 01METH261 )
  • Uniform 13C/15N labeling of DNA by tandem repeat amplification ( 01METH283 )
  • 2H-labeled RNA oligonucleotides in NMR studies ( 01METH320 )