The user must consider a series of criterias when design the general strategy and choose the required NMR methodoly for the structure elucidation and full spectral assignment of an unknown chemical compound. Thus, the main objective is to obtain the maximum and the most accurate information using the minimal spectrometer time.

Important parameters to take in account in terms of sensitivity, spectral dispersion, and chosen NMR experiments are the available spectrometer configuration, magnetic field and probehead. Thus, the possibility to perform selective excitation and gradient-enhanced spectroscopy is strongly recommended to obtain improved results in more reduced times. High magnetic fields afford better sensitivity and improved spectral dispersion. Optimized probeheads assures optimal sensitivity for the nucleus to be detected (for instance, inverse spectroscopy) and allows specific experiments to be recorded (for instance, triple resonance experiments).