NMR Periodic Table: Hydrogen NMR

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Hydrogen NMR

PHYSICAL PROPERTIES

Isotope	Natural Abundance (%)	Nuclear Spin (I)	Magnetogyric ratio *(10⁷rad/Ts)*	Quadruple moment *(10²⁸Q/m²)**	Resonance frequency (MHz) at 11.744T (500 MHz for ¹H)	Relative sensitivity (¹H=1.00)	Absolute sensitivity (¹H=1.00)
¹H	99.9885	1/2	26.7522128	0	500.000	1.00	1.00
²H	0.0115	1	4.10662791	2.8*10^-3	76.753	9.65*10^-6	1.45*10^-6
³H	0	1/2	28.5349779	0	533.317	1.21	0

APPLICATION FIELDS

Organic & organometallic chemistry
Biomolecules: Proteins, nucleic acids, polysaccharides and others
Labeled molecules with deuterium or tritium.

NMR REFERENCES

The accepted internal reference is tetramethylsilane [(CH3)₄Si or TMS] for ¹H and ³H and CDCl₃ for ²H. Also see IUPAC recommendations for reporting the NMR chemical shits of all nuclei relative to the ¹H resonance of TMS (02JMR323-156).

NMR PARAMETERS

¹H chemical shifts. The typical range is +10/0ppm although hydrogen nuclei involved in hydrogen bonding can appear in +20/+10ppm and resonances from transition metal hydrides can resonate in the range 0/-50ppm. ²H chemical shifts can be regarded as identical to ¹H chemical shifts.

Multiplet patterns and coupling constants.

Integration.

Relaxation properties.

NMR EXPERIMENTS

See eNMR for a complete list of multidimensional NMR experiments involving the ¹H nucleus.
1D ¹H spectrum
2D ¹H-¹H COSY experiment
2D ¹H-²H ( 92JMR243-100 and 84JMR515-56 ) and ¹H-³H ( 86MRC434 ) correlation experiments
2D ¹H-X HETCOR or HMQC/HSQC experiments in which X can be any active nucleus of the periodic table.

1D ²H spectrum
2D ²H-²H COSY experiment ( 87ANG156 ).
Selective 1D ²H TOCSY experiment ( 93MRC509 ).
2D ²H-X HETCOR experiment ( 84ORG468 , 85JACS1537 , and 92JMR243-100 ).
1D ³H spectrum.
2D ³H-³H COSY experiment ( 85TL5291 and 86MRC434 ).

BIBLIOGRAPHY

Deuterium and Tritium NMR: ( B79HAR107, 00ENC2366 )
High-resolution Solid State NMR ( 00ENC813 )

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